Sphingosine 1-phosphate lyase (SGPL1) insufficiency (SPLIS) is a syndrome which presents with adrenal insufficiency. steroid-resistant nephrotic syndrome. hypothyroidism. neurological disease. https://atlanticknifers.shop/product-category/coin-albums/
Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation
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