Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). It is unclear how changes to TDP-43. including nuclear to cytosolic translocation and subsequent accumulation. are controlled in these diseases. https://countryscenesaddleryandpetsuppliers.shop/product-category/western-show-tops/