Plasmid-mediated colistin resistance gene mcr-1 generally confers low-level resistance. The purpose of this study was to investigate the impact of mcr-1 on the development of high-level colistin resistance (HLCR) in Klebsiella pneumoniae and Escherichia coli. In this study. mcr-1-negative K. https://www.roneverhart.com/1998-2006-TOYOTA-SIENNA-3-3L-Van-Lower-Engine-Oil-Pan-3MZFE-Engine-6-Cylinder-T/